Histological Comparison between Biphasic Calcium Phosphate and Deproteinized Bovine Bone on Critical-Size Bone Defects

Abstract The limited options for bone repair have led to an extensive research of the field and development alloplastic xenogeneic grafts. purpose this study was evaluate with two substitutes: deproteinized bovine (DBB) biphasic calcium phosphate ceramic (BCP) in critical-size defect. A total 8-mm defects were made parietal bones rabbits (n=12). animals divided into three experimental groups: sham (defect filled a blood clot), DBB DBB), BCP BCP). After periods 15 45 days, euthanized submitted histomorphometric analysis. defect area, mineralized tissue biomaterial soft area evaluated. greater amount immature particles observed group compared at days (p<0.05). There no difference qualitative pattern deposition between BCP. However, did not show osteoid islands along defect, presenting collagen fibers as well relation groups. number inflammatory cells In conclusion, are optimizing use grafts maxillofacial rehabilitation. Bone treated showed days.